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| Product Name | Interferon alpha 4, Recombinant, Mouse (Interferon alpha-4, IFN-alpha-4, Ifna4) |
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| Description | Purity ~95% (Ion exchange, hydrophobic interaction and size exclusion chromatography). Most mammalian species have multiple IFN-a subtypes. Although the reasons for these multiple subtypes are not fully known, there are clear cell type and temporal differences in their expression. A recent study established a nomenclature for the murine IFN-a subtypes (van Pesch et al. 2004) and determined relative activities of the subtypes with protein quantification by phosphorimaging of metabolically-labeled protein. In this study, Mu IFN-a4 was deemed to have average antiviral activity when compared with the potency of the other subtypes. Mu IFN-a4 was initially cloned by Zwarthoff et al. [(1985) Nuc. Acids Res. 13(3) 791], and has been extensively studied. It is apparently expressed early in viral infection in a protein synthesis independent manner, and its expression is induced by phosphorylation of IRF-3. It may be that Mu IFN-a4, like IFN-b, has a priming function on cells, enabling the expres |
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| Size | 100KU |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NM_010504 |
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| Catalog # | I7661-75M |
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| Order / More Info | Interferon alpha 4, Recombinant, Mouse (Interferon alpha-4, IFN-alpha-4, Ifna4) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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