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| Product Name | Synuclein, alpha, Human, aa61-140 |
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| Description | Purity ~95% (SDS-PAGE). Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Two alternatively spliced transcripts of SNCA have been identified. Additional splicing may be present but the full-length nature of these variants has not been determined. Source: Human Synuclein, alpha, aa61-140, from E. coli. AA Sequence: MEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA An additional amino acid (Met) is attached at the N-terminus. Molecular Weight: 8,460 |
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| Size | 500ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Synuclein, alpha, Human, aa61-140 (SNCA, MGC110988, Alpha-synuclein, Non-A beta Component of AD Amyloid, Non-A4 Component of Amyloid Precursor, NACP, NACP, PARK1) |
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| Gene, Accession, CAS # | Accession: NM_000345.2, NM_007308.1, SwissProt: P37840 |
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| Catalog # | 217824 |
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| Order / More Info | Synuclein, alpha, Human, aa61-140 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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