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| Product Name | Synuclein, alpha, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE). A-synuclein is a small, soluble protein primarily expressed in neural tissue. The synuclein family includes three known proteins: alpha-synuclein, beta-synuclein, and gamma-synuclein. alpha-Synuclein is a very conserved, small acidic protein (140 residues) with a molecular weight of approximately 19kD that accounts for about 1% of total protein in neurons. It is concentrated primarily in presynaptic axon terminals and plays a central role in initiating Parkinson's disease. It is the principal constituent of Lewy bodies which are formed by protein aggregation and inclusion body formation.alpha-Synuclein lacks secondary or tertiary structure, so it belongs to the family of natively unfolded proteins, many of which act as chaperones. Much of this alpha-synuclein has been post-translationally modified to increase the rate of oligomerization. Mutant forms of alpha-Synuclein are associated with autosomal dominant Parkinson's disease. The mutations increase the aggrega |
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| Size | 200ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Synuclein, alpha, Recombinant, Human (NACP, SNCA, Alpha-synuclein, Non-A beta Component of AD Amyloid, Non-A4 Component of Amyloid Precursor, NACP, PARK1) |
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| Gene, Accession, CAS # | SwissProt: P37840 |
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| Catalog # | S9500-01Z |
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| Order / More Info | Synuclein, alpha, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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