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| Product Name | UGRP2, Recombinant, Human, aa21-104 (PnSP-2, HIN-1, High in Normal-1, SCGB3A1) |
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| Description | Purity ~90% (SDS-PAGE). High in Normal-1 (HIN-1), also known as Uteroglobin related protein 2 (UGRP2), is an 8kD secreted protein of the secretoglobin superfamily (SCGB3A1) (1). HIN-1 is expressed in bronchial epithelial and secretory Clara cells, mammary epithelial cells (particularly during pregnancy), salivary glands, and the prostate (2-5). It is up-regulated in Clara cells by IL-4, IL-13, Oncostatin M, EGF, and TGF-alpha and downregulated by IFNalpha, beta, and gamma (6-9). It is secreted into bronchial lavage fluid, saliva, and plasma, and may form disulfide-linked dimers (10). HIN-1 binds to the macrophage scavenger receptor MARCO, and to the surface of mammary and bronchial epithelial cells (11, 12). HIN-1 promotes apoptosis and inhibits the proliferation, migration, and invasion of breast cancer cells (12). The down-regulation of HIN-1 expression in many breast, lung, and prostate cancers correlates with hypermethylation of its promoter (4, 10, 13, 14). Mature human HIN-1 sh |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: Q96QR1 |
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| Catalog # | 145856 |
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| Order / More Info | UGRP2, Recombinant, Human, aa21-104 (PnSP-2, HIN-1, High in Normal-1, SCGB3A1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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