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| Product Name | UGRP2, Recombinant, Mouse |
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| Description | Purity ~95% (SDS-PAGE). High in Normal-1 also known as Uteroglobulin related protein 2 (UGRP2), is an 8kD secreted protein of the secretoglobin superfamily (SCGB3A1). HIN-1 is expressed in bronchial epithelial and secretory Clara cells, mammary epithelial cells (particularly during pregnancy), salivary glands, and the prostate. It is up-regulated in Clara cells by IL-4, IL-13, Oncostatin M, EGF, and TGF-a and down-regulated by IFNa B, and g. It is secreted into bronchial lavage fluid, saliva, and plasma and may form disulfide-linked dimers. HIN-1 binds to the macrophage scavenger receptor MARCO and to the surface of mammary and bronchial epithelial cells. HIN-1 promotes apoptosis and inhibits the proliferation, migration, and invasion of breast cancer cells likely through the Akt signaling pathway. The down-regulation of HIN-1 expression in many breast, lung, and prostate cancers correlates with hypermethylation of its promoter. Mature mouse HIN-1 shares 58% and 93% aa sequence identit |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | UGRP2, Recombinant, Mouse (Secretoglobin Family 3A Member 1, Cytokine HIN-1, High in Normal 1, Pneumo Secretory Protein 2, PnSP-2, Uteroglobin-related Protein 2, HIN1, PNSP2, SCGB3A1, UNQ629/PRO1245) |
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| Gene, Accession, CAS # | Accession: NP_473378 |
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| Catalog # | U7001-21 |
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| Order / More Info | UGRP2, Recombinant, Mouse from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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