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| Product Name | Bcl 2 Modi?ng Factor, NT, Blocking Peptide (Bmf) |
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| Description | Purified 60-70%. Synthetic peptide (EPSQCVEELEDDV) corresponding to amino acids 2 to 14 of human Bmf (1). This sequence differs from that of mouse by one amino acid. Apoptosis is related to many diseases and development. Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3-only proteins, including Bad, Bid, Bik, Hrk, Bim, Noxa, and PUMA, form a growing subclass of the Bcl-2 family. A novel BH3-only protein was recently identi?ed in human and mouse and designated Bmf (for Bcl-2-modi?ng factor) (1). The BH3 domain in Bmf is required both for binding to Bcl-2 proteins and for triggering apoptosis. In healthy cells, Bmf associates with the dynein light chain 2 (DLC2) component of the myosin V motors and is sequestered by the cell's actin cytoskeleton. Disruption of the actin cytoskeleton, either by depolymerization of actin ?laments or by detachment of cells from the extrac |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | ELISA WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | B0807-09P |
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| Order / More Info | Bcl 2 Modi?ng Factor, NT, Blocking Peptide (Bmf) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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