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| Product Name | Bcl 10, NT, Blocking Peptide (B Cell Leukemia 10, CIPER, mE10, CARMEN, CLAP) |
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| Description | Purity ~60-70%. Peptide corresponding to amino acids 5 to 19 of human origin (1-6). Apoptosis is related to many diseases including cancer. Cell death signals are transduced by death domain (DD) and caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include ARC, RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD containing protein was recently identified by several groups and designated Bcl10, CIPER, mE10, CARMEN, CLAP (1-6). Bcl10 is a cellular homolog of the equine Herpes virus-2 E-10 gene. Overexpression of Bcl10 induces JNK, p38, and NF-kB activation (1,2,4,6). Bcl10 interacts with caspase-9 and enhances pro-caspase-9 processing (3) and induces apoptosis through caspase-9 activation (3.6). BCL10 exhibits a variety of mutations in MALT lymphomas and in B and T cell lineage lymphomas indicating that it may be commonly involved in the pathogenesis of human malignancy (1,5). BCL10 is expressed in many human |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | B0807-13P |
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| Order / More Info | Bcl 10, NT, Blocking Peptide (B Cell Leukemia 10, CIPER, mE10, CARMEN, CLAP) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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