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| Product Name | RGS17, Recombinant, Human, aa1-210, His-Tag (Regulator of G-protein Signaling 17) |
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| Description | Purity ~90% (SDS-PAGE). RGS17, attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. It plays an important role in termination of signalling by mu opioid receptors and development of tolerance to opioid analgesic drugs. Source: Recombinant corresponding to aa1-210 from human RGS17, fused to His-tag at N-terminal expressed in E.coli. AA Sequence: MGSSHHHHHH SSGLVPRGSH MRKRQQSQNE GTPAVSQAPG NQRPNNTCCF CWCCCCSCSC LTVRNEERGE NAGRPTHTTK MESIQVLEEC QNPTAEEVLS WSQNFDKMMK APAGRNLFRE FLRTEYSEEN LLFWLACEDL KKEQNKKVIE EKARMIYEDY ISILSPKEVS LDSRVREVIN RNLLDPNPHM YEDAQLQIYT LMHRDSFPRF LNSQIYKSFV ESTAGSSSES Molecular Weight: ~26.5kD (MALDI-TOF) |
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| Size | 100ug, 500ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NP_036551 |
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| Catalog # | R1996-35 |
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| Order / More Info | RGS17, Recombinant, Human, aa1-210, His-Tag (Regulator of G-protein Signaling 17) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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