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| Product Name | ROCK2, Recombinant, Human, GST-tag |
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| Description | Purified (~70-90%). ROCK2 is a ubiquitously expressed serine/threonine kinase localized in the nucleus that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. ROCK2 is an immediate downstream target of the small GTPase RhoA. ROCK2 may play a pivotal role in cardiovascular diseases such as vasospastic angina, ischemic stroke, and heart failure. Inhibition of ROCKs by statins or other selective inhibitors leads to the upregulation and activation of endothelial nitric oxide synthase (eNOS) and reduction of vascular inflammation and atherosclerosis. Source: Recombinant protein corresponding to human ROCK2, fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~88kD Specific Activity: 575nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | ROCK2, Recombinant, Human, GST-Tag (Rho-associated Protein Kinase 2, Rho Kinase 2, KIAA0619, ROCK-II, ROKalpha) |
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| Gene, Accession, CAS # | Accession: NM_004850 |
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| Catalog # | 500427 |
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| Order / More Info | ROCK2, Recombinant, Human, GST-tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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