| 产品详情 |
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| Product Name | MK-2 Inhibitor IV, MK-25 |
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| Description | Purity ~95% (HPLC). A cell-permeable furanylcarboxamide compound that acts as a potent, reversible and non-ATP-competitive inhibitor of MK-2/MAPKAP-K2 activity (IC50=110nM; EC50=350nM for pHSP27 in IL-1b-stimulated SW1353 cells) with excellent selectivity over 150 kinases (% activity inhibition at 10uM against human CK2, Haspin, Arg and CK1y3=40, 40, 42 and >70, respectively). Shown to efficiently suppress the secretions of TNFa, IL6 (IC50=4.4 and 5.2uM in LPS-stimulated THP1 cell, respectively) and MMP-13 (IC50=5.7 and 2.2uM in IL1b-stimulated SW1353 and in primary osteoarthritis-derived chondrocytes, respectively). Exhibits desirable bioavailability and weakly inhibits a panel of cytochrome P450 isozymes (IC50>20uM for 3A4, 2D6 and 2C9). Formula: C27H25ClN4O2, HCl Solubility: DMSO Molecular Weight: 509.4 |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | MK-2 Inhibitor IV, MK-25 (MAPKAP-K2 Inhibitor IV, MK-25, 5-(4-Chlorophenyl)-N-(4-(piperazin-1-yl)phenyl)-N-(pyridin-2-ylmethyl)furan-2-carboxamide, HCl) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217557 |
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| Order / More Info | MK-2 Inhibitor IV, MK-25 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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