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| Product Name | MAT2A Inhibitor II, FIDAS-5 |
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| Description | Purity ≥98% (HPLC). A cell-permeable fluorinated N,N-dialkylaminostilbene (FIDAS) analogue of FIDAS-3 that competes against SAM for MAT2A binding and is >2-fold more potent than FIDAS-3 in inhibiting MAT2A-catalyzed SAM synthesis both in cell-free assays (IC50 = 2.1uM) and in LS174T colorectal cancer (CRC) cultures (3uM). FIDAS-5 at 3uM is shown to completely inhibit the proliferation of LS174T for up to 7 d in vitro and effectively suppress HT29 CRC tumor expansion in mice in vivo (20mg/kg/day p.o.). Primary Target: MAT2A Solubility: DMSO (100mg/ml) NMR: Conforms to structure LC-MS: Conforms to structure Elemental Analysis: C%: 69.79, H%: 5.90%, N%: 5.70% |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | MAT2A Inhibitor II, FIDAS-5 (FIDAS5, Methionine S-Adenosyltransferase 2A Inhibitor II, (E)-4-(2-Chloro-6-fluorostyryl)-N-methylaniline) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217533 |
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| Order / More Info | MAT2A Inhibitor II, FIDAS-5 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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