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| Product Name | PPM1D, Recombinant, Human, aa98-375, His-Tag |
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| Description | Purity ~90% (SDS-PAGE). PPM1D is also known as Protein phosphatase 1D magnesium-dependent, delta isoform. This protein is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase (MAPK/p38) through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. Source: Recombinant protein corresponding to aa98-375 from human PPM1D, fused to His-tag at N-terminus, expressed in E.coli. Molecular Weight: ~33.2kD (299aa) Applications: Suitable for use in SDS-P |
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| Size | 50ug, 250ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PPM1D, Recombinant, Human, aa98-375, His-Tag (Protein Phosphatase 1D Magnesium-Dependent, Delta Isoform) |
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| Gene, Accession, CAS # | Accession: AAH33893 |
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| Catalog # | 218469 |
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| Price | |
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| Order / More Info | PPM1D, Recombinant, Human, aa98-375, His-Tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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