| 产品详情 |
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| Product Name | CISH, Recombinant, Human, aa1-258, GST-Tag (Cytokine-inducible SH2-containing Protein) |
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| Description | Purity ~90% (SDS-PAGE). SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Source: Recombinant protein corresponding to aa1-258 from human CISH, fused to GST-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~55.7kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CIS-1 Protein G18 Suppressor of cytokine signaling |
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| Gene, Accession, CAS # | SwissProt: Q9NSE2 |
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| Catalog # | 372777 |
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| Order / More Info | CISH, Recombinant, Human, aa1-258, GST-Tag (Cytokine-inducible SH2-containing Protein) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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