| 产品详情 |
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| Product Name | Prostaglandin EP2 Receptor Antagonist, TG6-10-1 |
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| Description | Purity ~98% (HPLC). A cell-permeable, 3-acryl-acrylamide derivative that acts as a highly potent, selective, and competitive antagonist of prostaglandin E2 receptor (EP2, Kb = 17.8nM). Exhibits about 300-fold selectivity for the EP2 receptor over human EP3, EP4, and IP receptors, about 100- fold selectivity over human EP1, 25-fold selectivity against human FP and TP, and 10-fold selectivity against human DP1 receptors. Does not affect the activity of about 40 enzymes, ion channels, receptors, and neurotransmitters even at higher concentrations (?10uM). Shown to significantly reduce the induction of several inflammatory cytokines and chemokines and reduces the opening of blood-brain barrier during neuronal inflammation. Displays good pharmacokinetic properties with a half-life of 1.6 h and brain to plasma ratio of 1.6 in a murine model (5mg/kg i.p.). Solubility: DMSO Primary Target: EP2 Primary Target Ki: 17.8nM |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Prostaglandin EP2 Receptor Antagonist, TG6-10-1 ((E)-N-(2-(2-(trifluoromethyl)-1H-indol-1-yl)ethyl)-3-(3,4,5-trimethoxyphenyl)acrylamide, EP2 Antagonist, TG6-10-1) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217706 |
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| Order / More Info | Prostaglandin EP2 Receptor Antagonist, TG6-10-1 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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