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| Product Name | THPO, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE). Thrombopoietin, known also as TSF (thrombopoiesis stimulating factor), for mediator substances that function as natural stimulators of megakaryocytopoiesis and thus, promote the differentiation of platelets. Thrombopoietin stimulates an increase in the sizes and numbers of megakaryocytes. It also increases the number of small acetyl-cholinesterase positive cells that are early precursor cells of the megakaryocytic lineage. Thrombopoietin is a protein of 332aa that shows significant homology with Epo (erythropoietin) in its N-terminal domain. A comparison of human and porcine Thrombopoietin sequences shows 83 % identity between the erythropoietin-like domains but only 67% between the C-terminal domains. Source: Recombinant protein corresponding to human THPO expressed in E. coli. Molecular Weight: ~35kD Biological Activity: The ED50 as determined by the dose-dependent proliferation of Mo7e cells was found to be in the range of 1-2ng/mL. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | THPO, Recombinant, Human (C-Mpl Ligand, ML, Megakaryocyte Colony-Stimulating Factor, Megakaryocyte Growth and Development Factor, MGDF, Myeloproliferative Leukemia Virus Oncogene Ligand, Thrombopoietin) |
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| Gene, Accession, CAS # | SwissProt: P40225 |
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| Catalog # | 500496 |
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| Order / More Info | THPO, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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