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| Product Name | Thrombin, alpha, Bovine |
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| Description | Purity ≥95% by SDS-PAGE. Purified from prothrombin using a modification of the Lundblad procedure (1) as described by Nesheim, et al. (2). Purity is determined by SDS-PAGE analysis. Proteolytic Activation of Prothrombin: The serine protease a-thrombin is produced by proteolytic activation of the zymogen, prothrombin. The enzyme complex, prothrombinase, catalyzes the proteolysis of two peptide bonds in prothrombin, which gives rise to an NH2-terminal derived F1.2 region and the heterodimer, a-thrombin. Alpha-thrombin is a highly specific serine protease generated by proteolytic activation of the zymogen prothrombin (1). During coagulation, thrombin cleaves fibrinogen to form fibrin, leading to the ultimate step in coagulation, the formation of a fibrin clot. Thrombin is also responsible for feedback activation of the procofactors Factor V and Factor VIII. Thrombin has also been reported to activate Factor XIII and platelets. It also functions as a vasoconstrictor protein. The procoagula |
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| Size | 200ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | T4039 |
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| Order / More Info | Thrombin, alpha, Bovine from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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