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| Product Name | APP BioAssay™ ELISA Kit, Human |
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| Description | Sandwich ELISA quantitative detection kit for Human APP in cell culture supernates, serum and plasma (heparin, EDTA). Amyloid precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. Its primary function is not known, though it has been implicated as a regulator of synapse formation, neural plasticity and iron export. APP is best known and most commonly studied as the precursor molecule whose proteolysis generates beta amyloid (Aβ), a 39- to 42-amino acid peptide whose amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's disease patients. APP undergoes posttranslational proteolytic processing by alpha-, beta-, and gamma-secretases. Alpha-secretase generates soluble amyloid protein, while beta- and gamma-secretases generate APP components with amyloidogenic features. These 2 processing pathways are mutually exclusive. Assay Range: 312pg/ml-20,000pg/ml Sensitivity: |
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| Size | 96 tests |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Gene ID: 351, SwissProt: P05067 |
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| Catalog # | 143719 |
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| Order / More Info | APP BioAssay™ ELISA Kit, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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