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| Product Name | Transferrin Receptor 1, Human, Soluble, Control (TfR1) |
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| Description | Purified (~95%). Positive control for T8199-39B and T8199-46. Elemental iron is required for a variety of normal cellular functions and vital for proper growth and development. Transferrin (Tf), a serum glycoprotein of ~80kD and synthesized in the liver, is the primary protein of inter-organ transport of nonheme iron. Tf can bind two iron atoms. Tf binds to membrane Transferrin receptors (TfRs) and taken up by endocytosis. Iron is released from Tf, within acidic endosomes, into the cytoplasm apparently through the action of DMT1. The apoTf-TfR complex is returned to the cell surface, where, apo-Tf dissociates from TfR at the extracellular pH. The classical TfR, now termed TfR1, is a homodimeric (95kD subunits) type II membrane glycoprotein that binds two molecules of Tf. Human TfR1 (human 760aa; mouse 763aa) has a cytoplasmic domain 1-67aa, 68-88aa TM, and 89-760aa as extracellular domains. A monomeric serum form or soluble TfR1 (~80kD) also exists that lacks residues 1-100aa. A second |
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| Size | 100ul |
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| Concentration | n/a |
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| Applications | WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | T8199-45 |
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| Order / More Info | Transferrin Receptor 1, Human, Soluble, Control (TfR1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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