| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | Lasu1/Ureb1 |
|---|
| Clone | polyclonal |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | human |
|---|
| Isotype | n/a |
|---|
| Format | purified |
|---|
| Size | 100 µL |
|---|
| Concentration | n/a |
|---|
| Applications | Immunohistochemistry: 1:1,000-1:5,000, Immunoprecipitation: 2-5 µg/mg lysate, Western Blot: 1:2,000-1:10,000 |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | Lasu1/Ureb1 Polyclonal Antibody. The ARF tumor suppressor is a critical regulator of p53 stability. In addition to p53, ARF1 binds to other proteins such as MDM2 and ARF-BP1, a large protein containing HECT, UBA and WWE motifs. ARF-BP1 directly binds and ubiquitinates p53; this activity is inhibited by ARF, indicating that ARF-BP1 is a critical mediator of the p53-dependent and p53-independent tumor suppressor functions of ARF. ARF-BP1 can also catalyze the polyubiquitination of Mcl-1, an anti-apoptotic Bcl-2 family member involved in DNA damage-induced apoptosis. Elimination of ARF-BP1 expression by RNA interference stabilized Mcl-1 protein, resulting in an attenuation of apoptosis induced by DNA-damage agents. |
|---|
| Immunogen | n/a |
|---|
| Other Names | RP3-339A18.4, ARF-BP1, HECTH9, HSPC272, Ib772, LASU1, MULE, UREB1; ARF binding protein 1; ARF-binding protein 1; BJ-HCC-24 tumor antigen; E3 ubiquitin-protein ligase HUWE1; HECT domain protein LASU1; HECT, UBA and WWE domain-containing protein 1; Mcl-1 ubiquitin ligase E3; URE-B1; URE-binding protein 1; homologous to E6AP carboxyl terminus homologous protein 9; large structure of UREB1; upstream regulatory element-binding protein 1 |
|---|
| Gene, Accession # | Entrez: 10075; Uniprot: Q7Z6Z7 |
|---|
| Catalog # | A300-486A |
|---|
| Price | |
|---|
| Order / More Info | Lasu1/Ureb1 Antibody from INVITROGEN ANTIBODIES |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|