| 产品详情 |
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| Antigenic Specificity | CISD2 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 20 µg/mL, Immunofluorescence: 20 µg/mL, Immunohistochemistry: 2.5 µg/mL, Western Blot: 1-2 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CISD2 Polyclonal Antibody. Defects in the CISD2 (CDGSH iron sulfur domain 2) gene are a cause of the neurodegenerative disorder Wolfram syndrome 2. CISD2 is a zinc finger protein that localizes to the endoplasmic reticulum and mitochondria and binds an iron/sulfur cluster. CISD2 interacts with Bcl-2 and can be displaced by the BH3-only protein BIK and contributes to the regulation of BIK-initiated autophagy. CISD2 deficiency in mice causes mitochondrial breakdown accompanied by autophagic cell death as well as the development of premature aging phenotype. |
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| Immunogen | n/a |
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| Other Names | CISD2, CDGSH iron-sulfur domain-containing protein 2, endoplasmic reticulum intermembrane small protein, ERIS, mitoNEET related 1, miner1, nutrient-deprivation autophagy factor-1, NAF-1, zinc finger CDGSH-type domain 2, ZCD2, WFS2 |
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| Gene, Accession # | Entrez: 295457, 493856, 67006; Uniprot: Q8N5K1, Q9CQB5 |
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| Catalog # | PA5-34545 |
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| Price | |
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| Order / More Info | CISD2 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 28335035 |
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