| 产品详情 |
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| Antigenic Specificity | Puma BH3 Domain |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 400 µL |
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| Concentration | n/a |
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| Applications | Flow Cytometry: 1:10-1:50, Immunocytochemistry: 1:10-1:50, Immunofluorescence: 1:10-1:50, Immunohistochemistry (Paraffin): 1:10-1:50, Western Blot: 1:1000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Puma BH3 Domain Polyclonal Antibody. PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway. |
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| Immunogen | n/a |
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| Other Names | Bcl-2-binding component 3; p53 up-regulated modulator of apoptosis; JFY-1; BBC3 |
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| Gene, Accession # | Entrez: 27113; Uniprot: Q96PG8 |
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| Catalog # | PA5-11397 |
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| Price | |
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| Order / More Info | Puma BH3 Domain Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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