| 产品详情 |
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| Antigenic Specificity | LEF1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | fluorescein (FITC) conjugate |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | ELISA |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | LEF1 Antibody (FITC) LS-C499235. Specificity: Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells. |
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| Immunogen | Recombinant human Lymphoid enhancer-binding factor 1 protein (75-216AA) |
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| Other Names | LEF1, LEF-1, TCF7L3, TCF1-alpha, TCF10, TCF1ALPHA |
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| Gene, Accession # | LEF1, Gene ID: 51176 |
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| Catalog # | LS-C499235 |
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| Price | |
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| Order / More Info | LEF1 Antibody from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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