产品详情 |
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Antigenic Specificity | CD20 (human) |
Clone | CAT13.6E12 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2a |
Format | purified |
Size | 100 ug |
Concentration | n/a |
Applications | IHC, FACS |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Intermediate differentiation stage B-cell marker. Monoclonal antibody CAT13.6E12 recognizes the CD20 antigen. CD20 belongs to the MS4A family (membrane-spanning 4-domains subfamily A). Its expression is restricted to normal and neoplastic B-cells. It is expressed by pre-B-cells in the bone marrow, and expression persists during B-cell maturation but is lost upon terminal differentiation into plasma cells. CD20 is not glycosylated. CD20 is not phosphorylated in resting B-cells, but becomes heavily phosphorylated after mitogen stimulation. Three cell surface isoforms 33, 35 and 37kD, result from differential phosphorylation of a single core 33kD protein within the cytoplasmic domain. Multiple proteins are coimmunoprecipitated with CD20, suggesting that it may be a component of a multimeric surface receptor complex. Monoclonal antibodies against CD20 are used therapeutically, such as Rituximab (Mabthera) or Britumomab (Zevalin). Application: IHC (f), FACS |
Immunogen | n/a |
Other Names | n/a |
Gene, Accession # | n/a |
Catalog # | T-1371.0100 |
Price | |
Order / More Info | CD20 (human) Antibody from PENINSULA LABORATORIES INTERNATIONAL, INC.
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Product Specific References | n/a |
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