产品详情 |
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Antigenic Specificity | FOXP3 |
Clone | 206D |
Host Species | Mouse |
Reactive Species | human, cross-reactivity: cynomolgus, rhesus, baboon, pigtailed macaque |
Isotype | IgG1, κ |
Format | Alexa Fluor® 488 conjugate |
Size | 100 tests |
Concentration | n/a |
Applications | Intracellular Staining for Flow Cytometry (ICFC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Alexa Fluor® 488 anti-human FOXP3. FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in scurfy mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 δ2) lacking exon 2. The 206D antibody recognizes human FOXP3 epitope in the region of amino acids 105-235. |
Immunogen | Full-length FOXP3 protein |
Other Names | Forkhead box protein P3, Scurfin, JM2, IPEX, Zinc finger protein JM2 |
Gene, Accession # | Gene ID: 50943 |
Catalog # | 320112 |
Price | |
Order / More Info | FOXP3 Antibody from BIOLEGEND |
Product Specific References | PubMed: 16818678,17577038,17644734,17954571,18156502,18456875,18523152,18641304,18690669,19066178,19240164,19849846,20053943,24838938,25712684 |
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