| 产品详情 |
| Edit |   |
|---|
| Product Name | A-971432 |
|---|
| Description | An S1P5 agonist that is selective for S1P5 over S1P1 and S1P3 (IC50s = 0.006, 0.362, and >10 µM, respectively); inhibits forskolin-induced cAMP production in CHO cells expressing S1P5 (EC50 = 4.1 nM); increases electrical resistance of hCMEC/D3 cells in an in vitro blood-brain barrier model at 1 µM; attenuates blood-brain barrier leakage in an R6/2 transgenic mouse model of Huntington's disease at 0.1 mg/kg; decreases the number of errors made in a horizontal ladder task and increases latency to fall in the rotarod test in R6/2 mice at 0.1 mg/kg; increases spontaneous alternation in the t-maze in aged mice at 0.1 mg/kg, |
|---|
| Size | 10 mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | A971432 S1P-1 3 5 R2 BBB cyclic adenosine monophosphate Chinese hamster ovary R-6 |
|---|
| Gene, Accession, CAS # | CAS: 1240308-45-5 |
|---|
| Catalog # | 25326-10 |
|---|
| Price | |
|---|
| Order / More Info | A-971432 from CAYMAN CHEMICAL COMPANY |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|