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| Product Name | Recombinant Human STING Protein |
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| Description | Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Essential for the induction of IFN-beta in response to human herpes simplex virus 1 (HHV-1) infection. Exhibits 2',3' phosphodiester linkage-specific ligand recognition. Can bind both 2'-3' linked cGAMP and 3'-3' linked cGAMP but is preferentially activated by 2'-3' linked cGAMP.(Microbial infection) Antiviral activity is antagonized by oncoproteins, such as papillomavirus (HPV) protein E7 and adenovirus early E1A protein (PubMed: 26405230). Such oncoproteins prevent the ability to sense cytosolic DNA. |
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| Size | 50µg |
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| Concentration | 0.75mg/mL |
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| Applications | n/a |
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| Other Names | ERIS protein, Human; MITA protein ,Human; Transmembrane protein 173 |
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| Gene, Accession, CAS # | NP 938023.1 (Lys 137-Ser 379) |
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| Catalog # | PH0009E2-50µg |
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| Order / More Info | Recombinant Human STING Protein from LEADING BIOLOGY INC. |
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| Product Specific References | n/a |
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