| 产品详情 |
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| Antigenic Specificity | FOXP3 |
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| Clone | 22510 |
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| Host Species | Mouse |
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| Reactive Species | human, rat |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 1:1000, Immunofluorescence: 1:1000, Immunohistochemistry (Paraffin): 10 µg/mL, Western Blot: 1 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | FOXP3 Monoclonal Antibody (22510). FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene, and a more specific marker of regulatory T cells. Defects in the gene encoding FOXP3 protein cause the scurfy phenotype in mice. In humans FOXP3 defects play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also |
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| Immunogen | n/a |
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| Other Names | JM2, AIID, DIETER, IPEX, MGC141961, MGC141963, PIDX, XPID, FOXP3delta7; forkhead box protein P3; immune dysregulation, polyendocrinopathy, enteropathy, X-linked; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; scurfin |
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| Gene, Accession # | Entrez: 317382, 50943; Uniprot: Q9BZS1 |
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| Catalog # | MA5-14664 |
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| Price | |
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| Order / More Info | FOXP3 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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