产品详情 |
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Antigenic Specificity | Human TRX |
Clone | KN21-120 |
Host Species | Rabbit |
Reactive Species | human |
Isotype | IgG |
Format | unconjugated |
Size | n/a |
Concentration | n/a |
Applications | WB, ICC/IF, IHC, IP |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Rabbit Anti-Human TRX monoclonal antibody for WB, ICC/IF, IHC, IP. Thioredoxin (Trx) is a redox protein that is found in several species, such as bacteria, plants and mammals, and contains a conserved active site, consisting of Trp-Cys-Gly-Pro-Cys. Trx has several biological functions. It acts as a hydrogen donor for ribonucleotide reductase, which is critical for DNA synthesis, and modulates the DNA-binding activity of several transcription factors, including NFkB, AP-1, p53, TFIIIC and glucocorticoid receptor. Trx also stimulates cell growth, is an inhibitor of apoptosis and plays a role in the protection against oxidative stress. Drugs that inhibit Trx have antitumor activity, suggesting that Trx is involved in a variety of human diseases, including cancer. TrxR is a ubiquitously expressed flavoprotein that catalyzes the NADPH-dependent reduction of Trx as well as several other oxidized cellular components. |
Immunogen | Recombinant Protein |
Other Names | n/a |
Gene, Accession # | Gene ID: 7295, UniProt: P10599 |
Catalog # | DCABH-2760 |
Price | |
Order / More Info | Human TRX Antibody from CREATIVE DIAGNOSTICS |
Product Specific References | n/a |
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