| 产品详情 |
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| Product Name | GNF 5837 |
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| Description | Potent pan-Trk inhibitor. Displays antiproliferative effects in cellular Ba/F3 assays (IC50 values are 7, 9 and 11 nM for cells containing the fusion proteins Tel-TrkC, Tel-TrkB and Tel-TrkA, respectively). Exhibits selectivity for Trk receptors over a range of kinases, with some activity at PDGFR and c-Kit (IC50 values are 0.87 and 0.91 μM respectively). Orally bioavailable. Purity 98%. MW (observed): 535.49 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[3-[[2,3-Dihydro-2-oxo-3-(1H-pyrrol-2-ylmethylene)-1H-indol-6-yl]amino]-4-methylphenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]urea |
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| Gene, Accession, CAS # | CAS: 1033769-28-6 |
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| Catalog # | 4559/10 |
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| Order / More Info | GNF 5837 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 28604807 |
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| 产品资料 |
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