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| Product Name | Mouse Stem Cell Factor (SCF) Recombinant Protein |
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| Description | Mouse Stem Cell Factor (SCF) Recombinant Protein. Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in infl |
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| Size | 10 µg |
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| Concentration | lyophilized |
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| Applications | Control: Assay Dependent |
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| Other Names | M-SCF |
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| Gene, Accession, CAS # | Entrez: 17311; Uniprot: P20826 |
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| Catalog # | RP-8632 |
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| Order / More Info | Mouse Stem Cell Factor (SCF) Recombinant Protein from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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