| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | Nicastrin |
|---|
| Clone | polyclonal |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | human |
|---|
| Isotype | n/a |
|---|
| Format | purified |
|---|
| Size | 100 µL |
|---|
| Concentration | n/a |
|---|
| Applications | Immunoprecipitation: 2-10 µg/mg lysate, Western Blot: 1:500-1:2,500 |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | Nicastrin Polyclonal Antibody. Nicastrin, in addition to presenilin, PEN2, and APH-1 forms the -gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease. Like the tumor necrosis factor-a-converting enzyme (TACE) and the b-site cleavage enzyme (BACE) protease families, -gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting |
|---|
| Immunogen | n/a |
|---|
| Other Names | Ncstn |
|---|
| Gene, Accession # | Entrez: 23385; Uniprot: Q92542 |
|---|
| Catalog # | A304-464A |
|---|
| Price | |
|---|
| Order / More Info | Nicastrin Antibody from INVITROGEN ANTIBODIES |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|