| 产品详情 |
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| Antigenic Specificity | Nicastrin |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 20 µg/mL, Immunofluorescence: 20 µg/mL, Immunohistochemistry: 5 µg/mL, Western Blot: 0.5-2 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Nicastrin Polyclonal Antibody. Nicastrin, in addition to presenilin, PEN2, and APH-1 forms the -gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease. Like the tumor necrosis factor-a-converting enzyme (TACE) and the b-site cleavage enzyme (BACE) protease families, -gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting |
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| Immunogen | n/a |
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| Other Names | n/a |
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| Gene, Accession # | Entrez: 23385, 289231, 59287; Uniprot: P57716, Q8CGU6, Q92542 |
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| Catalog # | PA5-20303 |
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| Price | |
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| Order / More Info | Nicastrin Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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