| 产品详情 |
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| Antigenic Specificity | Presenilin 1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 20 µg/mL, Immunofluorescence: 20 µg/mL, Immunohistochemistry: 2.5 µg/mL, Western Blot: 0.5-2 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Presenilin 1 Polyclonal Antibody. Presenilin1 was initially identified a marker of susceptibility to early-onset Alzheimer's disease. In addition to PEN2, nicastrin and APH-1, Presenilin1 forms the -gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease. Like the tumor necrosis factor-alpha-converting enzyme (TACE) and the beta-site cleavage enzyme (BACE) protease families, -gamma-se |
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| Immunogen | n/a |
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| Other Names | AD3, FAD, PS-1, PS1, S182; presenilin-1 |
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| Gene, Accession # | Entrez: 19164, 29192, 5663; Uniprot: P49768, P49769, P97887 |
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| Catalog # | PA5-20376 |
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| Price | |
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| Order / More Info | Presenilin 1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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