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| Product Name | Active Recombinant Human Activin AB protein |
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| Description | Human recombinant protein expressed in Nicotiana benthamiana. It is produced by transient expression in non-transgenic plants. This product contains no animal-derived components or impurities. Animal Free product. Activins are homodimers or heterodimers of the various beta subunit isoforms, belonging to the TGFbeta family. Mature Activin AB has two chains of 116 and 123 amino acids residues (betaA-betaB). Activin exhibits a wide range of biological activities, including mesoderm induction, neural cell differentiation, bone remodelling, haematopoiesis, and reproductive physiology. Activins plays a key role in the production and regulation of hormones such as FSH, LH, GnRH and ACTH. Inhibins /Activins are proteins that are formed by the dimerization of two subunits, i. e. an alpha with either betaA -inhibin A- or betaB - inhibin B. The subunits betaA and betaB can also form homodimers or heterodimers calleds activins: Activin A (betaAbetaA), Activin B (betaBbetaB) and Activin AB (betaAbetaB). The activin gene family comprises the additional, but poorly characterized members activin betaC, betaD, and betaE. - As with other members of the super-family, Activins interact with two types of cell surface trans-membrane receptors (Types I and II) which have intrinsic serine/threonine kinase activities in their cytoplasmic domains, Activin type 1 receptors, ACVR1, ACVR1B, ACVR1C and Activin type 2 receptors, ACVR2A, ACVR2B. - The development of assays distinguishing between different forms of activins and inhibins, along with knock-in and knock-out models, have provided evidence that the betaA- and betaB-subunits have independent and separate roles physiologically. Additionally, evaluation of ligand-receptor interactions indicates significant differences in receptor affinity between activin isoforms, as well as between inhibin isoforms. Recombinant Activin AB is a disulphide linked heterodimer of subunits betaA / betaB . betaA Single chain, containing 116 aa (13.7 kDa) and betaB single chain, 123 amino residues (14kDa). Recombinant human Activin AB contains a His-tag at the N-terminal end. Purity >97% by SDS-PAGE gel |
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| Size | 1ug, 10ug, 50 µg |
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| Concentration | n/a |
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| Applications | Functional studies, Cell culture, Western Blot |
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| Other Names | Activin beta A beta B heterodimer |
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| Gene, Accession, CAS # | UniProt: P08476 P09529 |
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| Catalog # | RF0037 |
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| Order / More Info | Active Recombinant Human Activin AB protein from AGRENVEC |
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| Product Specific References | -Chen, Y. G. et al., 2006. Activin signalling and its role in regulation of cell proliferation, apoptosis, and carcinogenesis. Exp. Biol. Med. (Maywood), 231 (5): 534-44. -Bamberger, C. et al., 2005. Activin controls skin morphogenesis and wound repair predominantly via stromal cells and in a concentration-dependent manner via keratinocytes. Am. J. Pathol., 167 (3): 733-47. -Phillips, D. J. et al., 1999. A sensitive and specific in vitro bioassay for activin using a mouse plasmacytoma cell line, MPC-11. J. of Endocrinology, 162: 111-116. -Vale, W. et al., 1990. The inhibin / Activin family of hormones and growth factors. In Peptide Growth Factors and their Receptors: Handbook of Experimental Physiology, 95: 211-248. Eds. M Sporn & A Roberts. Berlin: Springer-Verlag. ? |
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