| 产品详情 |
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| Product Name | IGFBP-2 ELISA |
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| Description | The Eagle Biosciences ELISA for IGFBP-2 E05 is a so-called Sandwich-Assay using two specific and high affinity antibodies. The IGFBP-2 in the samples binds to the first antibody coated on the microtiter plate. In the following step the second specific anti-IGFBP-2-Antibody binds in turn to the immobilised IGFBP-2. The second antibody is biotinylated and will be applied in a mixture with a Streptavidin-Peroxidase-Enzyme Conjugate. In the closing substrate reaction the turn of the colour will be catalysed quantitatively depending on the IGFBP-2-level of the samples. Sample Types: serum, plasma, biological fluids. Range: 2 -80 ng/ml. Sensitivity: 0.2 ng/ml. Time: 2 hours • Insulin-like growth factors (IGFs) regulate the proliferation, differentation, apoptose, cell adhesion and metabolism in various tissues and cell types. The IGF-I, which is produced mainly in liver under the influence of growth hormone (GH), regulates as hormone the linear growth of the bones and the process of sexual maturity, while IGF-II is mainly a growth factor of fetal tissue. The biological actions of IGF over the IGF-Type-I receptor are modulated variably through the IGF binding proteins (IGFBP-1 to-6). IGFBP-2 is, after IGFBP-3, the second most frequent IGFBP in the human blood. IGFs, especially tumor typical pro-IGF-forms and hormones regulate the expression of IGFBP-2, GH effect is thereby inhibiting. At cellular level IGFBP-2 seems to stimulate the proliferation and dissemination of solid tumors via an IGF-independent mechanism. |
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| Size | 1 x 96 well |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | IGFBP-2, Insulin Growth Factor Binding Protein |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | E05 |
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| Order / More Info | IGFBP-2 ELISA from EAGLE BIOSCIENCES INC. |
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| Product Specific References | n/a |
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