| 产品详情 |
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| Antigenic Specificity | BUB1, aa281-419 |
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| Clone | monoclonal |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | Protein A purified |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | IF (1:500 - 1:2000), IP (1:200), WB (1:500 - 1:2000) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | BUB1 Antibody (aa281-419) LS-C45011. Detects Bub1, a protein kinase involved in spindle checkpoint function during mitosis. Bub1 co-operates with Aurora B kinase to inhibit Cdc20-mediated activation of the anaphase promoting complex/cyclosome (APC/C) until all the chromosomes correctly align on the microtubule spindle apparatus via their kinetochores, thus ensuring high fidelity mitotic chromosome segregation. Bub1 is also required for assembly of a functional inner centromere, sister chromatid cohesion via targeting of the Shugoshin protein, and metaphase congression. Mutation or aberrant Bub1 expression is associated with chromosomal instability, aneuploidy, and human cancer. |
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| Immunogen | Recombinant protein corresponding to amino acids 281-419 of human Bub1 protein. |
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| Other Names | BUB1, Bub1A, BUB1L, HBUB1 |
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| Gene, Accession # | BUB1, Gene ID: 699 |
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| Catalog # | LS-C45011 |
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| Price | |
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| Order / More Info | BUB1, aa281-419 Antibody from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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