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| Product Name | Pin1, 1-165aa, Mouse, His-tag, E.coli (Bioactivity Validated) |
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| Description | Purity: > 95 % by SDS - PAGE Format: Liquid. In Phosphate buffered saline (pH7.4) containing 10% glycerol. Pin1, also known as peptidyl-prolyl cis-trans isomerase NIMA-interacting1, is nuclear PPIase containing a WW protein interaction domain, and is structurally and functionally related to Ess1/Ptf1, an essential protein in budding yeast. Pin1 is thus an essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Substrates of Pin1 include the mitotic regulators (Cdc25 phosphatase and NIMA, PLK I, Wee, and Myt1 kinases), several transcription factors like beta-Catenin, c-Jun, and the tumor suppressor protein p53 , and some specific proteins like the RNA Pol II, the cytoskeleton protein tau, and the G1/S protein Cyclin D1. Recombinant mouse PIN1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. |
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| Size | 100ug, 20ug, 4ug |
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| Concentration | n/a |
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| Applications | Enzyme activity |
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| Other Names | Peptidyl-prolyl cis-trans isomerase NIMA-interacting1, 0610025L01Rik, D9Bwg1161e |
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| Gene, Accession, CAS # | NP 075860 |
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| Catalog # | ATGP3566 |
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| Order / More Info | Pin1, 1-165aa, Mouse, His-tag, E.coli (Bioactivity Validated) from ATGen |
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| Product Specific References | n/a |
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