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| Product Name | CXCR4, Recombinant, Human, aa303-352, His-Tag (C-X-C Chemokine Receptor Type 4) |
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| Description | Purity ~85% (SDS-PAGE). Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for human immunodeficiency virus-1/HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Source: Recombinant protein corresponding to aa303-352 |
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| Size | 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P61073 |
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| Catalog # | 370575 |
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| Order / More Info | CXCR4, Recombinant, Human, aa303-352, His-Tag (C-X-C Chemokine Receptor Type 4) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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