产品名称 carboxypeptidase M Antibody from DENDRITICS SAS
产品货号 DDX0520
产品价格 现货询价,电话:010-67529703
产品规格 100µg/50µg
产品品牌 DENDRITICS SAS
产品概述
产品详情
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Antigenic Specificitycarboxypeptidase M
CloneM27.23
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG1
Formatpurified
Size100µg/50µg
Concentrationn/a
ApplicationsFACS, IP, IHC frozen section
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DescriptionMonoclonal antibody (MoAb) M27 was generated after immunization of mice with the human B-lineage acute lymphoblastic leukemia cell line Pre-ALP. Under reducing conditions, MoAb M27 precipitated a 60-kD surface-membrane molecule from Pre-ALP cells. Expression cloning of Pre-ALP cDNA showed that M27 recognizes carboxypeptidase M (CPM), a cell-surface, zinc-dependent protease known to cleave off basic C-terminal amino acids from peptide hormones. Using M27 antibody, CPM was detected only at discrete B lymphocyte developmental stages, namely on committed precursors and on germinal center cells. CPM was also expressed on mature T cells, mainly after activation. These results provide the first description of a carboxy-peptidase on lymphoid cells. In addition, CPM was found on granulocytes and monocytes but not on their progenitors. CPM was found to be expressed with CD10 and CD13 respectively on lymphoid and myeloid cells. (de Saint Vis B et al., Blood 1995,86,1098-105)
Immunogenn/a
Other Namesn/a
Gene, Accession #n/a
Catalog #DDX0520
Price
Order / More Infocarboxypeptidase M Antibody from DENDRITICS SAS
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