| 产品详情 |
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| Antigenic Specificity | DC-SIGN/CD209 |
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| Clone | 120C8 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2b,k |
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| Format | purified |
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| Size | 100µg/50µg |
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| Concentration | n/a |
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| Applications | FACS surface, HIV gp120 binding studies |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | DC-SIGN (``DC Specific, ICAM-3 Grabbing, Nonintegrin'') / CD209 is a type II membrane protein with an external mannose-binding C-type lectin domain, DC-SIGN is expressed by immature and mature dendritic cells (DC). In the skin, DC-SIGN+ DC are exclusively located in the dermis. DC-SIGN binds to ICAM-3 on resting T cells, establishing DC-T cell contact and adaptive immunity. DC-SIGN is a high affinity receptor for HIV gp120, allowing HIV capture and transmission to CD4+ T cells. In addition to HIV, DC-SIGN is a receptor for a number of other viral and cellular pathogens including Mycobacterium tuberculosis, and is a major player in microbial evasion of the immune system. (Geijtenbeek, T and al, Cell, 2000, 100: 587-597- van Kooyk Y and al, Nat Rev Immunol, 2003 3: 697-709). |
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| Immunogen | n/a |
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| Other Names | DC Specific, ICAM-3 Grabbing, Nonentegrin |
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| Gene, Accession # | n/a |
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| Catalog # | DDX0208 |
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| Price | |
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| Order / More Info | DC-SIGN/CD209 Antibody from DENDRITICS SAS |
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| Product Specific References | n/a |
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