| 产品详情 |
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| Antigenic Specificity | Abeta-pE11 |
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| Clone | 173D8 |
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| Host Species | Mouse |
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| Reactive Species | human, rat, mouse |
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| Isotype | IgG2b |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | IHC, Paraffin Sections (FFPE), Frozen Sections, Western Blot, Immunocytochemistry, ELISA |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Amyloid deposits, also called plaques, of Alzheimer's patients consist of several protein components like the amyloid beta-peptides (Abeta, Aβ) 1-40/42 and additional C- and N-terminally truncated and modified fragments. Very abundant are the isoaspartate (isoAsp)-Abeta and pyroglutamyl (pGlu)-Abeta peptides. The latter are formed by cyclization of the N-terminal glutamate at position 3 or 11 catalyzed by glutaminyl cyclase (QC) resulting in very amyloidogenic and neurotxic variants of Abeta; Abeta-pE3 and Abeta pE11. In contrast to extracellular plaques that do not perfectly correlate with Alzheimer?s disease intraneuronal Abeta accumulation and vascular Abeta deposits have gained more and more evidence to be among the crucial factors responsible for progressive neuron loss. |
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| Immunogen | Synthetic peptide pyr-EVHHQK-C coupled to key-hole limpet hemocyanin via an added C-terminal cysteine residue. |
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| Other Names | pE-Abeta; pGlu-Abeta; Abeta(11(pE)-40; 42); pyro-glu-Abeta |
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| Gene, Accession # | APP, 351 |
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| Catalog # | SySy218811 |
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| Price | |
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| Order / More Info | Abeta-pE11 Antibody from DIANOVA GmbH |
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| Product Specific References | n/a |
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