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| Product Name | Antibody to Trastuzumab ELISA Assay Kit |
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| Description | This ImmunoGuide anti-drug antibody(ies) (ADA) kit is a bridging type ELISA for the determination of free antibodies against the drug Trastuzumab in serum and plasma samples. During the first incubation period, ADA in serum or plasma samples are captured by the drug coated on the microtiter wells. After washing away the unbound components from samples, a peroxidase-labelled drug conjugate is added and then incubated. ADA, if present in sample, will make a bridge, with its identical Fab arms, between the drug coated on the well and the other drug molecule labelled with peroxidase. After a second washing step, the bound enzymatic activity is detected by addition of tetramethylbenzidine (TMB) chromogen-substrate. Finally, the reaction is terminated with stop solution. The positive reaction is expected to be related to the presence of ADA in the sample. Sample Types: serum, plasma. Range: Cut-off. Sensitivity: Cut-off. Time: 2.5 hours • The drug Trastuzumab (trade names Herceptin®, Herclone®) is a recombinant DNA-derived humanized monoclonal antibody that selectively targets the extracellular domain of the human epidermal growth factor receptor 2 protein (HER2). The antibody is an IgG1 kappa that contains human framework regions with the complementarity-determining regions of a murine anti-p185 HER2 antibody that binds to HER2. According to the prescribing information, the use of Trastuzumab might be associated to the development of anti-Trastuzumab antibodies in various percentages of patients during therapy with the drug. The ImmunoGuide Antibody to Trastuzumab ELISA Kit can be efficiently used for monitoring Anti-Trastuzumab antibodies during therapy and offers the clinician a tool for decision on possible preventive measures. |
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| Size | 1 x 96 well |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | anti-drug antibody kits, anti drug shikari shakari herceptin, herclon, Ab, Antibodies, Antibody, ELISA Assay Kit EIA, Immunoassay, Free Trastuzumab Herceptin Herclon TR-S-ATT, ATT, IG-BB105, Tani |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | IG-BB105 |
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| Order / More Info | Antibody to Trastuzumab ELISA Assay Kit from EAGLE BIOSCIENCES INC. |
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| Product Specific References | n/a |
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