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| Antigenic Specificity | AAK1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Immunoprecipitation: 2-5 µg/mg lysate, Western Blot: 1:2,000-1:10,000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | AAK1 Polyclonal Antibody. AP2-associated protein kinase 1 (Aak1) is a member of the Ark1/Prk1 subfamily of Ser/Thr protein kinases that are thought to regulate endocytosis by phosphorylating the accessory endocytic components. Aak1 interacts with and phosphorylates the mu2 subunit of the AP-2 complex, which promotes binding of the AP-2 to tyrosine based (Yxxphi) internalization motif-containing receptors and subsequent receptor endocytosis. At least two isoforms of Aak1 are known to exist; the longer isoform contains an extended carboxy-terminus that contains an additional clathrin-binding domain. Overexpression of this long isoform or Aak1 depletion by RNA interference impairs transferrin recycling from the early/sorting endosome, suggesti |
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| Immunogen | n/a |
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| Other Names | AP2-associated protein kinase 1; Adaptor-associated kinase 1; AAK1; KIAA1048 |
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| Gene, Accession # | Entrez: 22848; Uniprot: Q2M2I8 |
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| Catalog # | A302-145A |
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| Price | |
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| Order / More Info | AAK1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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