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| Antigenic Specificity | AANAT |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 50 µg |
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| Concentration | n/a |
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| Applications | Immunofluorescence: 5-10 µg/mL, Western Blot: 0.5 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | AANAT Polyclonal Antibody. Pineal gland serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AA-NAT) is an ~23 kDa protein which is the rate-limiting enzyme in melatonin synthesis. Melatonin serves as the hormonal signal of the daily light/dark cycle, or body clock. The nocturnal oscillation in enzyme activity ranges by 10- to 100-fold depending on species among vertebrates. Studies have shown that AA-NAT is regulated by cAMP at both the mRNA and protein levels. AA-NAT has putative protein kinase A (PKA) sites at Thr29 and Ser206. Phosphorylation of AA-NAT at these residues might play a role in protein inactivation via proteasome-dependent degradation. |
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| Immunogen | n/a |
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| Other Names | Serotonin N-Acetyltransferase |
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| Gene, Accession # | Entrez: 25120; Uniprot: Q64666 |
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| Catalog # | PA1-762 |
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| Price | |
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| Order / More Info | AANAT Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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