| 产品详情 |
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| Product Name | A-443654 |
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| Description | Purity >98%. Three related forms of the kinase Akt (1, 2, 3, also known as protein kinase B isoforms PKBAlpha, Beta, Gamma) modulate cell proliferation, metabolism, and survival as well as angiogenesis. A-443654 is an inhibitor of Akt (Ki = 160 pmol/L for all three isoforms) that interferes with mitotic progression and bipolar spindle formation. It induces G2 /M accumulation, defects in centrosome separation, and formation of either monopolar arrays or disorganized spindles. A-443654 has been reported to slow the progression of Akt-dependent tumors in in vivo mouse models. In response to an A-443654-induced decrease in phosphorylation of Akt targets, a concomitant increase in Thr308 and Ser473 phosphorylation of Akt has been observed in human cancer cell lines. A-443654 has been used to examine the mechanism of this rapid feedback reaction. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | aS-[[[5-(3-methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]-1H-indole-3-ethanamine |
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| Gene, Accession, CAS # | CAS: 552325-16-3 |
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| Catalog # | LS-H6353 |
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| Order / More Info | A-443654 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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