| 产品详情 |
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| Product Name | A-769662 |
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| Description | Purity >98% (NMR, HPLC). A-769662 is a potent and reversible AMP-activated protein kinase (AMPK) allosteric activator. Activates AMPK by binding to the b and g subunits and not the AMP binding site. EC50=0.8 mM for purified rat liver AMPK and inhibits fatty acid biosynthesis in rat hepatocytes IC50=3.2 mM. A-769662 inhibits the rate of whole-body fatty acid oxidation, decreases body weight gain, reduces plasma and liver triglycerides and lowers plasma glucose in ob/ob mice. Inhibits adipocyte differentiation. Prevents transcriptional activation of Oct4 and establishes a metabolic barrier to induced pluripotent stem cell reprogramming. A-769662 synergizes with AICAR. Cell permeable. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-Hydroxy-3-(2'-hydroxy-[1,1'-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile |
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| Gene, Accession, CAS # | CAS: 844499-71-4 |
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| Catalog # | LS-H14577 |
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| Price | |
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| Order / More Info | A-769662 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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