| 产品详情 |
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| Product Name | A-804598 |
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| Description | Purity >98%. A-804598 is a potent and selective competitive antagonist of the purinergic P2X7 receptor, a ligand-gated ion channel, with IC50 values of 9.9 and 10.9 nM in 132N1 cells transfected with the rat or mouse receptor, respectively. It inhibits IL-1Beta release in human THP-1 cells stimulated with LPS and IFN-Gamma (IC50 = 8.5 nM). A-804598 is selective for P2X7 receptors over other P2X and P2Y receptors at concentrations up to 100 µM and over many G protein-coupled receptors, enzymes, transporters, and ion channels. A-804598 (25 mg/kg) prevents footshock-induced increases in IL-1Beta mRNA in the paraventricular nucleus of the rat hypothalamus. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-cyano-N''-[(1S)-1-phenylethyl]-N'-5-quinolinyl-guanidine |
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| Gene, Accession, CAS # | CAS: 1125758-85-1 |
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| Catalog # | LS-H6365 |
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| Order / More Info | A-804598 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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