| 产品详情 |
| Edit |   |
|---|
| Product Name | AAL-993 |
|---|
| Description | Purity >95%. AAL-993 is a potent inhibitor of VEGF receptors, inhibiting VEGFR1, 2, and 3 with IC50 values of 130, 23, and 18 nM, respectively. It less potently inhibits c-Kit, colony stimulating factor 1 receptor, PGDF receptor Beta, and EGF receptor (IC50 s = 236, 380, 640, and 1,040 nM, respectively) and is without effect on a number of other tyrosine kinases. AAL-993 is orally bioavailable in vivo, blocks VEGF-induced angiogenesis, and prevents the growth of primary tumors and spontaneous peripheral metastases in mice. It also inhibits hypoxia-mediated increase in hypoxia-inducible factor-1 transcriptional activity in an ERK-dependent manner (IC50 = ~5 µM). |
|---|
| Size | n/a |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | 2-[(4-pyridinylmethyl)amino]-N-[3-(trifluoromethyl)phenyl]-benzamide, VEGFR Tyrosine Kinase Inhibitor VI, ZK 260253 |
|---|
| Gene, Accession, CAS # | CAS: 269390-77-4 |
|---|
| Catalog # | LS-H6367 |
|---|
| Price | |
|---|
| Order / More Info | AAL-993 from LIFESPAN BIOSCIENCES INC. |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|