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| Product Name | PCSK2, Recombinant, Human |
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| Description | Purity ~90% (SDS-PAGE, reducing conditions). Endotoxin:≤1EU/1ug (LAL). Proprotein Convertase 2 (PCSK2) is a subtilisin-like serine peptidase that processes proteins into biologically active products in the secretory pathway. Like other furin/kexin family members, PCSK2 cleaves its substrates primarily after sites of paired basicaaresidues. Autoactivation of PCSK2 occurs in a post-Golgi compartment of the secretory system. Interaction with the secretory protein 7B2 is required for proper activation of PCSK2. The N-terminal domain of 7B2 stabilizes active PCSK2, and a C-terminal fragment of 7B2 can inhibit PCSK2 activity. rhPCSK2 was coexpressed with 7B2 to facilitate activation of the enzyme. PCSK2 is a major proteolytic processing enzyme of the regulated secretory pathway of the neuroendocrine system, where it generates a number of hormones and neuropeptides. Products of PCSK2 processing include enkephalins, insulin, somatostatin, dynorphin, and LHRH. Chinese Hamster Ovary cell line, |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PCSK2, Recombinant, Human (Neuroendocrine Convertase 2, NEC 2, KEX2-like Endoprotease 2, Prohormone Convertase 2, Proprotein Convertase 2, PC2, NEC2) |
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| Gene, Accession, CAS # | SwissProt: P16519 |
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| Catalog # | P9052-11C |
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| Order / More Info | PCSK2, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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