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| Product Name | Semaphorin 3C, Fc Chimera, Recombinant, Human |
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| Description | Purity ≥ 95% by SDSPAGE under reducing conditions and visualized by silver stain. Human Semaphorin 3C/Fc Chimera Semaphorin 3C (Sema3C; previously SemaE) is one of six Class 3 secreted semaphorins which share 40-50% aa identity among themselves. Class 3 semaphorins are potent chemorepellents that function in axon and/or vascular guidance during development, and may be upregulated in tumor progression (1, 2). The 751aa human Sema3C is highly modular. It contains a 20aa signal sequence, an ~500aa N-terminal Sema domain that forms a beta-propeller structure similar to that found in integrin molecules, a cysteine knot, a furin-type cleavage site, an Ig-like domain, and a C-terminal basic domain (1-3). Covalent dimerization plus cleavage at the C-terminus are required for activity of class 3 semaphorins (4). Human Sema3C shares at least 95% aa identity with mouse, rat, cow and dog Sema3C, and 89% and 75% aa identity with chick and zebrafish Sema3C, respectively. Type 3 semaphorins transduc |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: Q99985 |
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| Catalog # | S0668-49A |
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| Price | |
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| Order / More Info | Semaphorin 3C, Fc Chimera, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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